WP5 Review of Existing Clinical Trials and Observational Studies

WP objectives:

  • To systematically review published randomized clinical trials to provide overall effect estimates for the outcomes of interest of drug therapies in T2DM.
  • To systematically review published pharmacoepidemiological studies on the safety of therapies in T2DM to synthesize the evidence, and where possible, provide a summary effect estimate for each of the safety outcomes of interest.
  • To identify and synthesize methodological issues and research gaps of available pharmacoepidemiological studies.